Paliperidone - oral

Patient Medicine Information
Why do I need this medicine?
Paliperidone is used to treat schizophrenia (an illness that causes changes in perception, thoughts and behaviour).

This medicine may also be used on its own or together with other medicines to treat schizoaffective disorder (a mental illness that can be experienced in addition to the symptoms of schizophrenia).

Paliperidone helps relieve symptoms common in schizophrenia and schizoaffective disorder, such as agitation, distress, distorted thinking and emotional instability.
How do I take this medicine?
Take Paliperidone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Take it constantly either always with food or always without food. Try to take it at the same time each day.

If you are taking the prolonged-release type of tablet, swallow it whole with a glass of water. Do not divide, chew or crush the tablet.

The dose of Paliperidone will be decided by your doctor. Your doctor will advise you on the treatment regimen depending on your condition, response and tolerability to this medicine.

Paliperidone must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
DO NOT take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Paliperidone or similar medicine such as risperidone.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • heart or blood vessel disease e.g. heart rhythm disorder, heart failure, heart attack, stroke
  • kidney disease
  • liver disease
  • diabetes or at risk for diabetes e.g. obesity, family history
  • swallowing, stomach or intestine disorder that may reduce your ability to swallow or pass foods by normal bowel movement
  • history of blood clot disorder
  • epilepsy (fits or seizures), including those with history of seizures, head trauma, brain damage, alcoholism
  • hyperprolactinaemia (high prolactin levels in the blood)
  • dementia (group of symptoms affecting thinking and social abilities)
  • Parkinson’s disease (a brain disease that affects movement)
  • neuroleptic malignant syndrome (a neurological disorder characterised by muscle rigidity, fever and blood pressure changes)
  • tardive dyskinesia (a condition which causes uncontrollable twitching movements of the mouth, tongue and limbs)
If you are going for an operation such as an eye surgery, inform your doctor that you are taking Paliperidone.

Be sure to check with your doctor or pharmacist before giving Paliperidone to a child or an elderly. Children and elderly may be more sensitive to the side effects.

Paliperidone may cause your white blood cell count to drop drastically. This may put you at higher risk for infections. For as long as you are being treated with Paliperidone, you will need to have regular blood tests done. These blood tests are very important for you. These tests help your doctor to check that your white blood cell counts are within the normal range. Your doctor will advise you about how often you need to have these blood tests.

Paliperidone may also cause your blood sugar levels to rise. Monitor your blood sugar levels more regularly if you have diabetes or a family history of diabetes. Ask your doctor how often you need to have your blood sugar levels monitored.

Paliperidone may affect the ability of your body to adjust to temperature changes in the environment. Avoid exposure to very cold or very hot environments. Avoid strenuous exercise and activities like going to the sauna. Drink more water to prevent dehydration.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Your doctor may need to do certain tests to make sure that your heart, lungs, liver, and kidney function is normal before you take this medicine and thereafter depending on your doctor’s advice.
  • Routine tests (e.g. complete blood count, electrolyte, blood cholesterol/lipid, glucose test, eye examination) may be done while you are being treated with this medicine. Your doctor will advise you about how often you will need to have these tests.
For as long as you are taking this medicine, you may need to regularly monitor your blood pressure and weight.
What side effects could I experience?
Paliperidone may cause drowsiness, dizziness or some problems with your eyesight. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects include any of the following: weight gain, loss of appetite, difficulty sleeping, headache, tremor, cough, stomach pain, nausea, vomiting, constipation, diarrhoea, indigestion, dry mouth, and back or joint pain.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of an allergic reaction e.g. rashes, breathlessness, swelling of the mouth, face, lips, tongue, or throat
  • signs of blood clot in your veins e.g. pain and swelling in your legs
  • signs of stroke e.g. sudden weakness or numbness of your face, arms or legs (especially on one side), slurred speech
  • unusual changes in mood or behaviour (being too depressed, agitated, or having compulsive and impulsive behaviour)
  • signs of tardive dyskinesia e.g. twitching or jerking movements that you cannot control in your face, tongue, or other parts of your body
  • signs and symptoms of heart or blood pressure problems e.g. fast or slow heart rate, irregular heartbeat, lightheadedness or dizziness when you get up from a sitting or lying down position
  • fever or abnormally high body temperature
  • continuous, prolonged, painful erection in men
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for heart disease e.g. amiodarone, sotalol, quinidine, disopyramide
  • medicine for allergies e.g. mizolastine
  • medicine for malaria e.g. mefloquine
  • strong painkiller e.g. tramadol
  • other medicine for mood disorders e.g. clozapine
  • medicine for nausea or vomiting e.g. metoclopramide
  • medicine for Parkinson’s disease e.g. levodopa
  • medicine for epilepsy e.g. carbamazepine
This list does not include all medicines that may interact with Paliperidone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on paliperidone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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