View Parin-E overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to either enoxaparin Na, heparin or its derivatives including other LMWH. Patients w/ acute bacterial endocarditis, active major bleeding & conditions w/ a high risk of uncontrolled haemorrhage, including recent haemorrhagic stroke, thrombocytopenia in patients w/ +ve in-vitro aggregation test in the presence of enoxaparin; active gastric or duodenal ulceration; in patients receiving heparin for treatment rather than prophylaxis, locoregional anaesth in elective surgical procedures.
History of heparin-induced thrombocytopenia w/ or w/o thrombosis. Thrombocytopenia. Conditions w/ increased potential for bleeding. Risk of hyperkalaemia. Potential intra-spinal haematomas or spinal puncture resulting in long term or permanent paralysis w/ spinal/epidural anaesth. Increased enoxaparin exposure in renal impairment, low-wt women (<45 kg) & low-wt men (<57 kg).
Discontinue concurrent admin of agents which affect haemostasis prior to enoxaparin therapy unless their use is essential, eg, systemic salicylates, acetylsalicylic acid, NSAIDs including ketorolac, dextran, & clopidogrel, systemic glucocorticoids, thrombolytics & anticoagulants.
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