enoxaparin sodium


Venus Remedies


Ni Lay Naing
Concise Prescribing Info
Enoxaparin Na
Acute DVT; acute ST-segment elevation MI. Prophylaxis of DVT; ischemic complications of unstable angina & non-Q-wave MI.
Dosage/Direction for Use
SC Dose adjustments for therapeutic ranges: 1 mg/kg bd; 1.5 mg/kg bd; 30 mg-single IV bolus + 1 mg/kg SC dose followed by 1 mg/kg bd. Elderly >75 yr Acute STEMI 0.75 mg/kg bd w/o initial bolus. Dose adjustments for prophylaxis: 20 mg bd; 40 mg bd.
Hypersensitivity to either enoxaparin Na, heparin or its derivatives including other LMWH. Patients w/ acute bacterial endocarditis, active major bleeding & conditions w/ a high risk of uncontrolled haemorrhage, including recent haemorrhagic stroke, thrombocytopenia in patients w/ +ve in-vitro aggregation test in the presence of enoxaparin; active gastric or duodenal ulceration; in patients receiving heparin for treatment rather than prophylaxis, locoregional anaesth in elective surgical procedures.
Special Precautions
History of heparin-induced thrombocytopenia w/ or w/o thrombosis. Thrombocytopenia. Conditions w/ increased potential for bleeding. Risk of hyperkalaemia. Potential intra-spinal haematomas or spinal puncture resulting in long term or permanent paralysis w/ spinal/epidural anaesth. Increased enoxaparin exposure in renal impairment, low-wt women (<45 kg) & low-wt men (<57 kg).
Adverse Reactions
Hemorrhage; thrombocytosis, thrombocytopenia. Allergic reaction, hepatic enzyme increase, urticaria, pruritus, erythema; inj site hematoma, pain, other inj site reaction.
Drug Interactions
Discontinue concurrent admin of agents which affect haemostasis prior to enoxaparin therapy unless their use is essential, eg, systemic salicylates, acetylsalicylic acid, NSAIDs including ketorolac, dextran, & clopidogrel, systemic glucocorticoids, thrombolytics & anticoagulants.
ATC Classification
B01AB05 - enoxaparin ; Belongs to the class of heparin group. Used in the treatment of thrombosis.
Parin-E soln for inj 40 mg/0.4 mL
Parin-E soln for inj 60 mg/0.6 mL
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