Paromomycin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Intestinal amoebiasis 25-35 mg/kg/day in 3 divided doses for 5-10 days. Hepatic encephalopathy As adjunctive therapy: 4 g/day in divided doses for 5-6 days.
Dosage Details
Oral
Hepatic encephalopathy
Adult: As adjunctive therapy: 4 g daily in divided doses at regular intervals for 5-6 days.

Oral
Intestinal amoebiasis
Adult: 25-35 mg/kg daily in 3 divided doses for 5-10 days.
Child: Same as adult dose.
Administration
Should be taken with food. Take during meals.
Contraindications
Hypersensitivity to paromomycin and other aminoglycosides. Intestinal obstruction.
Special Precautions
Patient w/ ulcerative bowel lesions. Prolonged use may result in overgrowth of non-susceptible organisms. Renal impairment. Pregnancy and lactation.
Adverse Reactions
Ototoxicity, anorexia, nausea, vomiting, epigastric burning and pain, increased GI motility, abdominal cramps, diarrhoea, pruritus ani, hypocholesterolaemia, malabsorption of xylose and sucrose, abnormal fat metabolism, headache, vertigo, eosinophilia, exanthema, unexplained haematuria.
Potentially Fatal: Pseudomembranous colitis, nephrotoxicity, neuromuscular blockade.
Action
Description: Paromomycin acts directly on amoeba. It has antibacterial activity against normal and pathogenic organisms in the GI tract and interferes w/ bacterial protein synthesis by binding to 30S ribosomal subunits.
Pharmacokinetics:
Absorption: Poorly absorbed from the GI tract.
Excretion: Via faeces (approx 100% of the dose, as unchanged drug); via urine (approx 0.1%).
Chemical Structure

Chemical Structure Image
Paromomycin

Source: National Center for Biotechnology Information. PubChem Database. Paromomycin, CID=165580, https://pubchem.ncbi.nlm.nih.gov/compound/Paromomycin (accessed on Jan. 22, 2020)

Storage
Store between 15-30°C. Protect from moisture.
References
Anon. Paromomycin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/10/2014.

Buckingham R (ed). Paromomycin Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 22/10/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Paromomycin Sulfate . AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 22/10/2014.

Paromomycin Sulfate Capsule (Heritage Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/10/2014.

Disclaimer: This information is independently developed by MIMS based on Paromomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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