Khandelwal Lab


Ni Lay Naing
Concise Prescribing Info
Locally advanced or metastatic nonsquamous non-small cell lung cancer: Initial treatment in combination w/ cisplatin; maintenance treatment for whom disease has not progressed after 4 cycles of platinum-based 1st-line chemotherapy; single-agent treatment after prior chemotherapy. Malignant pleural mesothelioma for whom disease is either unresectable or are otherwise not candidates for curative surgery (in combination w/ cisplatin).
Dosage/Direction for Use
Premed may be administered prior to therapy. Combination use w/ cisplatin: Malignant pleural mesothelioma Recommended dose: 500 mg/m2 IV infusion over 10 min on day 1 of each 21-day cycle. Recommended dose of cisplatin: 75 mg/m2 infused over 2 hr beginning approx 30 min after the end pemetrexed administration. Single-agent use: Nonsquamous non-small cell lung cancer Recommended dose: 500 mg/m2 IV infusion over 10 min on day 1 of each 21-day cycle.
History of severe hypersensitivity to pemetrexed.
Special Precautions
Not for squamous cell non-small cell lung cancer. Low-dose oral folic acid prep or multivit w/ folic acid may be taken on a daily basis to reduce toxicity. Required laboratory monitoring of ANC, platelet count & CrCl. Patients w/ clinically significant 3rd space fluid. Use caution when administering concurrently w/ NSAIDs to patients w/ mild to moderate renal insufficiency. Hepatic & renal impairment. Pregnancy & lactation. Childn.
Adverse Reactions
Fatigue, nausea & anorexia. Vomiting, neutropenia, leukopenia, anemia, stomatitis or pharyngitis, thrombocytopenia & constipation.
Drug Interactions
Concomitant administration of nephrotoxic drugs & tubularly secreted substances (eg, probenecid) could result in delayed clearance of pemetrexed. Patients w/ mild to moderate renal insufficiency should avoid taking NSAIDs for 2 days before, the day of & 2 days following administration of pemetrexed.
ATC Classification
L01BA04 - pemetrexed ; Belongs to the class of antimetabolites, folic acid analogues. Used in the treatment of cancer.
Pemxcel lyophilized powd for infusion 100 mg
Pemxcel lyophilized powd for infusion 500 mg
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