Pentaerythrityl tetranitrate


Concise Prescribing Info
Indications/Uses
Angina pectoris.
Dosage/Direction for Use
Adult : PO 40-240 mg/day in divided doses.
Dosage Details
Oral
Angina pectoris
Adult: 40-240 mg daily in divided doses before a meal.
Administration
Should be taken on an empty stomach. Take before meals & at bedtime.
Contraindications
Severe hypotension, heart failure, marked anaemia, hypertrophic obstructive cardiomyopathy, patients with cerebral haemorrhage or head trauma, low cardiac output secondary to hypovolaemia, inferior MI with right ventricular involvement, raised intracranial pressure.
Special Precautions
Severe hepatic or renal impairment, hypothyroidism, malnutrition, hypothermia. Cerebrovascular disease, lung disease or cor pulmonale. Pregnancy, lactation, glaucoma, mitral valve prolapse, cardiac tamponade, syncope.
Adverse Reactions
Flushing of the face, dizziness, tachycardia, throbbing headache and tolerance. Large dose can cause vomiting, restlessness, hypotension, syncope, rarely cyanosis and methaemoglobinaemia, impaired respiration, bradycardia. Nausea, urinary and faecal incontinence, abdominal pain, apprehension, weakness, vertigo.
Potentially Fatal: Paradoxical bradycardia, impaired respiration and collapse.
Overdosage
Treat syncope and hypotension by keeping patient in recumbent position with head lowered. Severe poisoning: oxygen admin with assisted respiration, plasma expanders or electrolyte solutions to maintain circulation. IV methylthioninium to treat methaemoglobinaemia. Severe poisoning with tablets: stomach lavage (charcoal if ingested within 1 hr).
Drug Interactions
Enhances bioavailability of dihydroergotamine. Hypotensive effects may be enhanced by alcohol and vasodilators such as ACE inhibitors.
Potentially Fatal: Orthostatic hypotension may be produced by combined use of Ca channel blockers, antihypertensives, phenothiazines and tricyclic antidepressants. Alcohol may cause severe hypotension and collapse.
Lab Interference
False-positive decrease in serum cholesterol.
Action
Description: Pentaerythrityl tetranitrate exerts a vasodilating effect through release of nitric oxide causing stimulation of guanylate cyclase in the vascular smooth muscle cells thus inducing relaxation. It also has a coronary vasodilator effect which improves regional coronary blood flow to ischaemic areas resulting in improved O2 supply to the myocardium.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Pentaerythrityl tetranitrate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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