Phenazopyridine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Pain and irritability in cystitis, prostatitis and urethritis 200 mg 3 times/day. W/ an antibiotic, max duration: 2 days.
Dosage Details
Oral
Pain and irritability in cystitis, prostatitis and urethritis
Adult: As hydrochloride: 200 mg tid. When combined with an antibiotic, max duration of treatment is 2 days, although lower doses for at least a wk have been given.
Child: As hydrochloride: 12 mg/kg/day in 3 divided doses for 2 days.
Renal Impairment
CrClDosage
<50Avoid.
50-80Give dose every 8-16 hr.
Administration
Should be taken with food.
Contraindications
Impaired renal function or severe hepatitis. CrCl <50 ml/min.
Special Precautions
Avoid prolonged use. Pregnancy and lactation. G6PD deficiency. Stop treatment if skin or sclerae discolouration occur. Elderly.
Adverse Reactions
GI disturbances, headache; rash; hepatotoxicity; haemolytic anaemia, methaemoglobinaemia; discolouration of urine and other body fluids; staining of contact lens; crystal deposits in urinary tract.
Potentially Fatal: Acute renal failure.
Overdosage
Symptoms: Methaemoglobinaemia, haemolytic anaemia, skin pigmentation, renal and hepatic impairment. Treatment: Use methylene blue for methaemoglobinaemia.
Lab Interference
May interfere with urine ketone and protein tests. May delay reactions with glucose oxidase reagents. May occasionally cause false-positive tests with Tes-Tape.
Action
Description: Phenazopyridine is an azo dye that exerts an analgesic effect in the urinary tract.
Pharmacokinetics:
Absorption: Absorbed from the GI tract (oral).
Excretion: Via urine (65% as unchanged drug; 18% as paracetamol).
Disclaimer: This information is independently developed by MIMS based on Phenazopyridine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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