Piperazine


Concise Prescribing Info
Indications/Uses
Listed as Dosage.
Dosage/Direction for Use
Adult : PO Ascariasis As hydrate: 4.5 g as a single dose, repeated once after 14 days. Enterobiasis As hydrate: 2.25 g once daily for 7 days. May repeat 2nd course after 7 days.
Dosage Details
Oral
Ascariasis
Adult: As hydrate: 4.5 g as a single dose repeated once after 14 days. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose mthly for up to 3 mth if needed; same dosage regimen may also be used to prevent ascariasis.
Child: As a single dose, repeated once after 14 days. <1 yr: 120 mg/kg (only upon medical advice), 1-3 yr: 1.5 g, 4-5 yr: 2.25 g, 6-8 yr: 3 g, 9-12 yr: 3.75 g. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose mthly for up to 3 mth if needed; same dosage regimen may also be used to prevent ascariasis.

Oral
Enterobiasis
Adult: As hydrate: 2.25 g once daily for 7 days, 2nd course may be repeated after an interval of 7 days. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose after 14 days.
Child: <1 yr: 45-75 mg/kg (only upon medical advice), 1-3 yr: 750 mg, 4-6 yr: 1.125 g, 7-12 yr: 1.5 g, >12 yr: same as adult dose. To be taken once daily for 7 days, 2nd course may be repeated after an interval of 7 days. Alternatively, for children >6 yr: May be given as a preparation with senna in a single dose of 4 g of the phosphate; repeat dose after 14 days.
Administration
May be taken with or without food.
Contraindications
Severe renal impairment, epilepsy. Pregnancy.
Special Precautions
Hepatic impairment, neurological conditions, mild to moderate renal impairment. Lactation.
Adverse Reactions
Nausea, vomiting, colic, abdominal pain, diarrhoea, urticaria, skin rashes, headache, bronchospasm, dizziness, nystagmus, ataxia, paraesthesia, myoclonic contractions, choreiform movements, muscular incoordination (worm wobble), confusion, EEG abnormalities, blurred vision.
Potentially Fatal: Stevens-Johnson syndrome, bronchospasm and angioedema.
Drug Interactions
Antagonism if pyrantel and piperazine are used together. Piperazine may potentiate extrapyramidal effects of chlorpromazine and other phenothiazines.
Action
Description: Piperazine is effective against the intestinal nematodes roundworm (Ascaris lumbricoides), pinworm and threadworm (Enterobius vermicularis). It produces a neuromuscular block resulting in muscle paralysis of the worms which are consequently dislodged and expelled in the faeces.
Pharmacokinetics:
Absorption: Readily absorbed from the GIT (oral).
Distribution: Distributes into breast milk.
Excretion: Via urine (as metabolites).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Piperazine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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