Pirenzepine


Concise Prescribing Info
Indications/Uses
Peptic ulcer.
Dosage/Direction for Use
Adult : PO 50 mg 2-3 times/day for 4-6 wk.
Dosage Details
Oral
Peptic ulcer
Adult: 50 mg bid-tid for 4-6 wk.
Administration
Should be taken on an empty stomach. Take 30 min before meals.
Special Precautions
Impaired renal function, esp end-stage renal failure.
Adverse Reactions
Dry mouth, blurred vision.
Drug Interactions
Enhanced effect when used other drugs with antimuscarinic properties and MAOIs. May affect absorption of other drugs. Antagonistic effect with parasympathomimetics.
Food Interaction
Decreased bioavailability when taken with food.
Action
Description: Pirenzepine is a selective M1 tertiary amine antimuscarinic. It decreases gastric acid secretion through preferential action on gastric mucosa; also reduces pepsin secretion.
Pharmacokinetics:
Absorption: Bioavailability: 20-30%. Reduced when taken with food.
Distribution: 12% bound to plasma proteins. Poor diffusion across blood brain barrier.
Excretion: About 10% excreted unchanged in urine, the rest in faeces. Elimination half life: 12 hr.
Disclaimer: This information is independently developed by MIMS based on Pirenzepine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in