Pivampicillin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Gonococcal urethritis 1.5 g as a single dose w/ 1 g of probenecid. Bacterial infections 0.5 g twice daily. May double dose in serious infections.
Dosage Details
Oral
Gonococcal urethritis
Adult: 1.5 g as a single dose in association with probenecid 1 g.

Oral
Bacterial infections
Adult: 500 mg bid. Dose may be doubled in serious infections.
Child: 3 mth-1 yr: 40-60 mg/kg daily in 2 divided doses. >1 yr: 12.5-17.5 mg/kg bid, up to 500 mg bid. >10 yr: 500 mg bid.
Contraindications
Hypersensitivity, infectious mononucleosis, porphyria.
Special Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum K concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Increased risk of developing skin rash in patients with lymphatic leukaemia or HIV infection. May cause carnitine deficiency.
Adverse Reactions
Hypersensitivity reactions including urticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropaenia; thrombocytopaenia; CNS toxicity including convulsions; antibiotic-associated colitis. GI effects; pseudomembranous colitis; erythematous maculopapular erruptions.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Probenecid prolongs T1/2 of pivampicillin. May cause prolonged bleeding time when used with anticoagulants. May reduce efficacy of oral contraceptives. Antacids may reduce the absorption of pivampicillin. Increased risk of carnitine deficiency when used with valproate.
Lab Interference
May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Action
Description: Pivampicillin is a prodrug of ampicillin which exerts its killing action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis.
Pharmacokinetics:
Absorption: Readily absorbed.
Metabolism: Hydrolysed to ampicillin, pivalic acid and formaldehyde.
Excretion: About 70% of a dose is excreted in the urine as ampicillin within 6 hr.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Pivampicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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