Adult: A course of treatment w/ a blood schizontocide should be given 1st to kill any erythrocytic parasites. 15 mg daily for 14 days, increased to higher doses or longer course if resistance in P. vivax occurs. Child: 250 mcg/kg once daily for 14 days. Max: 15 mg daily.
Special Patient Group
Patients w/ G6PD deficiency: Up to 45 mg or 750 mcg/kg once every 7 days for 8 wk.
Should be taken with food. Take w/ meals to avoid GI discomfort.
Acutely ill patients suffering from systemic disease manifested by tendency to develop granulocytopenia (e.g. rheumatoid arthritis, lupus erythematosus). Concurrent use w/ other potentially haemolytic drugs or depressants of myeloid elements of the bone marrow. Concomitant admin w/ mepacrine.
Enhanced effect w/ other drugs that prolong the QT interval. Potentially Fatal: Concomitant use w/ other bone marrow depressants or haemolytics can increase the possibility of adverse haematological effects. Mepacrine may increase plasma concentrations and potentiate toxicity of primaquine.
Description: Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P. vivax, P. ovale and P. falciparum by disrupting mitochondria and binding to DNA. Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: Approx 1-2 hr. Distribution: Widely distributed throughout body tissues. Apparent volume of distribution: Approx 150-250 L. Metabolism: Undergoes rapid hepatic metabolism and converted to carboxyprimaquine (major metabolite). Excretion: Via urine as unchanged drug in small amounts. Elimination half-life: 3-6 hr.
P01BA03 - primaquine ; Belongs to the class of aminoquinoline antimalarials.
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