Pristinamycin


Concise Prescribing Info
Indications/Uses
Susceptible infections.
Dosage/Direction for Use
Adult : PO 2-4 g/day in divided doses.
Dosage Details
Oral
Susceptible infections
Adult: 2-4 g/day in divided doses.
Contraindications
Hypersensitivity.
Special Precautions
Pseudomembranous colitis.
Adverse Reactions
GI disturbances; hypersensitivity reactions.
Drug Interactions
May increase serum levels of ciclosporin.
Action
Description: Pristinamycin is a streptogramin antibacterial which reversibly binds to 50s subunit of bacterial ribosome blocking the transpeptidation and inhibiting protein synthesis of susceptible bacteria thus inhibiting cell growth. Its spectrum of activity includes many gm+ve and some gm-ve bacteria, as well as mycoplasmas, spirochetes, chlamydias and rickettsias. It is active against staphylococci and some streptococci. N. gonorrheae and H. influenzae are sensitive. There is cross-resistance with macrolides and lincosamides.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Pristinamycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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