Procaine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Inj Percutaneous infiltration anesth As 0.25 or 0.5% soln: 350-600 mg. Peripheral nerve block As a 0.5, 1 or 2% soln: 0.5-1 g
Dosage Details
Injection
Percutaneous infiltration anaesthesia
Adult: 350-600 mg using 0.25 or 0.5% solutions.

Injection
Peripheral nerve block
Adult: 500 mg procaine HCl as a 0.5%, 1% or 2% solution. Up to 1 g may be used.
Contraindications
Hypersensitivity, complete heart block. Not to be applied to inflamed or traumatised surfaces, low plasma-cholinesterase conc, not to be instilled into the middle ear. Generalised septicaemia. Epidural or spinal block should not be used in patients with cerebrospinal diseases, cardiogenic/hypovolaemic shock or altered coagulation states.
Special Precautions
Epilepsy; impaired cardiac conduction or resp function; shock; hepatic impairment; myasthenia gravis. Those who received the anesthetic for procedures e.g. laryngoscopy or tracheoscopy should not eat or drink for 3-4 hr after anaesthetic. Patients should be warned not to rub or touch the eye while anesthesia persists and protect anesthetised eye from dust and bacterial contamination. Avoid application on to extensive areas for prolonged periods. Pregnancy. Elderly, debilitated and paediatrics.
Adverse Reactions
CNS excitation; dizziness; tinnitus; blurred vision; nausea and vomiting; muscle twitching and tremors; convulsions. Numbness of tongue and perioral region. Bradycardia; arrhythmias. Hypersensitivity; methemoglobinemia; foetal intoxication; corneal damage.
Potentially Fatal: Severe hypotension leading to cardiac arrest.
Drug Interactions
May antagonise the activity of aminosalicylic acid or sulfonamides. May enhance the neuromuscular blocking activity of suxamethonium and the amide local anaesthetics.
Action
Description: Procaine acts by stabilising the neuronal membrane thus preventing the generation and transmission of impulses along nerve fibers and at nerve endings. In general, loss of pain occurs before loss of sensory, autonomic and motor functions. A PABA ester, it does not penetrate intact mucous membranes well making it ineffective against surface application and admin is solely by injection.
Pharmacokinetics:
Absorption: Rapidly absorbed following parenteral admin.
Distribution: About 6% bound to plasma proteins.
Metabolism: Rapidly hydrolysed by plasma cholinesterases.
Excretion: About 80% excreted unchanged or conjugated in urine.
Storage
Store at 20-25°C.
Disclaimer: This information is independently developed by MIMS based on Procaine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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