Procaterol


Generic Medicine Info
Indications and Dosage
Inhalation/Respiratory
Asthma, Chronic bronchitis, Pulmonary emphysema
Adult: For the relief of dyspnoea or other symptoms caused by respiratory obstructive disturbance: As dry powder inhaler: Usual dose: 20 mcg (2 puffs) as directed up to 4 times daily. Dosage may be adjusted according to the severity of symptoms and patient age.
Elderly: Dosage adjustment may be required.

Oral
Asthma, Chronic bronchitis, Pulmonary emphysema
Adult: For the relief of dyspnoea or other symptoms caused by respiratory obstructive disturbance: As tab or syr: 50 mcg once daily before bedtime, or 50 mcg bid (in the morning and before bedtime). Dosage must be adjusted according to the severity of symptoms and patient age.
Child: May refer to specific product guideline.
Elderly: Dosage adjustment may be required.
Administration
May be taken with or without food.
Special Precautions
Patient with heart disease, hypertension, hyperthyroidism, diabetes mellitus. Not a substitute for inhaled corticosteroids or other anti-inflammatory agents. Elderly. Pregnancy and lactation.
Adverse Reactions
Significant: May exacerbate hyperthyroidism or diabetes mellitus; increased blood pressure, acute asthma episodes (during prolonged use for bronchial asthma); palpitations, exacerbated heart disease; shock, anaphylactoid reactions; decreased serum K levels.
Ear and labyrinth disorders: Tinnitus.
Gastrointestinal disorders: Nausea, vomiting, dry mouth, gastric discomfort.
General disorders and administration site conditions: Generalised malaise or fatigue.
Musculoskeletal and connective tissue disorders: Muscle spasticity.
Nervous system disorders: Headache or dull headache, tremors, dizziness, numbness of limbs, drowsiness.
Psychiatric disorders: Insomnia.
Respiratory, thoracic and mediastinal disorders: Nasal congestion, tracheopharyngeal abnormal feeling.
Skin and subcutaneous tissue disorders: Rash, pruritus, cold sweat.
Vascular disorders: Facial flushing.
Potentially Fatal: Cardiac arrhythmias or arrest (continuous excessive doses).
Monitoring Parameters
Closely monitor serum K levels (particularly in hypoxic patients); signs and symptoms of shock or anaphylactoid reactions.
Overdosage
Oral: Symptoms: Tachycardiac arrhythmia, hypotension, tremor, nervousness, hypokalaemia, hyperglycaemia. Management: Perform gastric lavage, if necessary. Provide emergency treatment and general maintenance therapy, if necessary. In case of serious tachycardiac arrhythmia, careful administration of β-blockers (e.g. propranolol) may be considered.
Drug Interactions
May result in aggravated decrease in serum K levels and cardiac adverse effects with corticosteroids (e.g. betamethasone, hydrocortisone), xanthine derivatives (e.g. theophylline), and diuretics (e.g. furosemide).
Potentially Fatal: Catecholamines (e.g. epinephrine, isoprenaline) potentiate the adrenoceptor stimulating effects of procaterol, which may lead to arrhythmias or cardiac arrest.
Lab Interference
May suppress skin reactions in allergen testing.
Action
Description: Procaterol, a direct-acting sympathomimetic with predominantly β-adrenoceptor stimulant action selective to β2-adrenergic receptors, is a bronchodilator with similar activity to salbutamol.
Onset: Within 5 minutes (inhalation).
Duration: Up to 8 hours (inhalation).
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 1.3±0.7 hours (oral); 15 minutes (inhalation).
Excretion: Via urine (oral: 9.93% or 11.65%; inhalation: 14.36%).
Chemical Structure

Chemical Structure Image
Procaterol

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4916, Pro-Air. https://pubchem.ncbi.nlm.nih.gov/compound/Pro-Air. Accessed Mar. 26, 2021.

Storage
Store below 30°C. Protect from light.
MIMS Class
Antiasthmatic & COPD Preparations
ATC Classification
R03AC16 - procaterol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
R03CC08 - procaterol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
References
Brezu 5 mcg/mL Syrup (Otsuka [Philippines] Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 03/03/2021.

Buckingham R (ed). Procaterol Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/03/2021.

Meptin 25 and 50 mcg Tablet (Otsuka [Philippines] Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 03/03/2021.

Meptin Swinghaler (Thai Otsuka Pharmaceutical Co., Ltd.). MIMS Thailand. http://www.mims.com/thailand. Accessed 03/03/2021.

Meptin Swinghaler 10 mcg/puff Powder For Inhalation (Otsuka [Philippines] Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 03/03/2021.

Disclaimer: This information is independently developed by MIMS based on Procaterol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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