Pyrantel


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Susceptible single or mixed worm infections 10 mg/kg as a single dose. Ascariasis 5 mg/kg as a single dose. Max: 1 g/dose. Mass treatment of ascariasis 2.5 mg/kg as a single dose given 3-4 times/yr. Enterobiasis 10 mg/kg repeated once after 2-4 wk. Max: 1 g/dose. Trichinosis 10 mg/kg/day for 5 days.
Dosage Details
Oral
Single or mixed infections due to susceptible worms
Adult: 10 mg/kg as a single dose.
Child: 10 mg/kg as a single dose.

Oral
Trichinosis
Adult: 10 mg/kg daily for 5 days.

Oral
Necatoriasis
Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days.

Oral
Enterobiasis
Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose.

Oral
Ascariasis
Adult: 5 mg/kg as a single dose. Max: 1 g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr.
Administration
May be taken with or without food.
Special Precautions
Liver dysfunction, anaemia or severe malnutrition. Treat members in close contact with the patient.
Adverse Reactions
Anorexia, nausea, vomiting, abdominal cramps, drowsiness, insomnia, diarrhoea, tenesmus, SGOT elevations, headache, dizziness, rash.
Drug Interactions
Potentially Fatal: Mutually antagonistic with piperazine.
Action
Description: Pyrantel is effective against roundworms (Ascaris), threadworms (Enterobius), hookworms and Trichostrongylus. Not effective against whipworm. Acts by paralysing the worms which get detached and are excreted by intestinal peristalsis.
Pharmacokinetics:
Absorption: Minimally absorbed from the GI tract (oral).
Excretion: Via urine (7% as unchanged drug and metabolites), via faeces (>50% as unchanged).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Pyrantel from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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