Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: The recommended daily dose of Ridlor is 75 mg once daily.
Acute Coronary Syndrome: For patients with non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), Ridlor should be initiated with a single 300-mg loading dose and then continued at 75 mg once daily. Aspirin (75 mg-325 mg once daily) should be initiated and continued in combination with Ridlor. For patients with ST-segment elevation acute myocardial infarction, the recommended dose of Ridlor is 75 mg once daily, administered in combination with aspirin, with or without thrombolytics. Ridlor may be initiated with or without a loading dose.
CYP2C19 poor metabolizer status is associated with diminished response to clopidogrel. The optimal dose regimen for poor metabolizers has yet to be determined.
No dosage adjustment is necessary for elderly patients or patients with renal disease.