Rupatadine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Allergic rhinitis; Chronic idiopathic urticaria 10 mg once daily.
Dosage Details
Oral
Allergic rhinitis, Chronic idiopathic urticaria
Adult: 10 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Avoid alcohol.
Special Precautions
Renal or hepatic insufficiency. May impair ability to drive or operate machinery. Pregnancy, lactation. Elderly, children <12 yr.
Adverse Reactions
Headache, somnolence, fatigue/asthenia.
Drug Interactions
Increased CNS depressant effects when used with CNS depressants or alcohol.
Action
Description: Rupatadine acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors. Rupatadine also antagonises the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction and lead to an increase in the vascular permeability, acting as mediators in the inflammatory process.
Pharmacokinetics:
Metabolism: Liver - mainly by CYP450.
Disclaimer: This information is independently developed by MIMS based on Rupatadine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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