In patients with ventricular arrhythmias, adjustment to the antiarrhythmic requires careful cardiologic monitoring and may only be carried out if cardiologic emergency equipment is available and monitoring control possible.
Posology with single and daily dose: As saturation dose 600 mg amiodarone per day (200 mg amiodarone 3 times per day) for 8-10 days.
In some cases, doses of up to 1200 mg amiodarone per day (200 mg amiodarone 6 times per day) may become necessary.
Afterwards, reduction to a maintenance dose, usually 200 mg amiodarone per day for 5 days per week.
In some cases, higher doses of 200-600 mg amiodarone per day (1-3 times 200 mg amiodarone) are required during long-term therapy.
Special note: As most of adverse reactions are dose-dependent, the lowest effective maintenance dose should be administered.
Paediatric population: The safety and efficacy of amiodarone in children has not been established.
Currently available data are described in Pharmacology: Pharmacodynamics and Pharmacokinetics under Actions.
In children, the dose should be adjusted according to the body surface or body weight.
Method and duration of administration: The tablets should be taken unchewed during or after meals together with sufficient liquid.
The attending physician decides on the duration of administration.