Each capsule also contains the following excipients: Lactose, hydroxypropyl methylcellulose, croscarmellose sodium and magnesium stearate.
Tacrolimus has a chemical name of [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate.
Tacrolimus is an odorless and tasteless white crystalline powder. It is very hygroscopic and the compound is isolated from cultures of Streptomyces tsukabaensis, strain No. 9993. The drug binds strongly to polyvinyl chloride and polyurethane plastics.