Adult Patients in Renal Transplantation: Recommended Initial Oral Dose: 0.2 mg/kg/day in 2 divided doses to be administered every 12 hrs. Whole blood concentration during month 1-3 should be maintained between 7-20 ng/mL, and 5-15 ng/mL during the 4th month and onwards. The first dose should be administered after the renal function has recovered (ie, serum creatinine <4 mg/dL). Dosing should be titrated based on clinical assessments of rejection and tolerability. Lower Seegraf dosages may be sufficient as maintenance therapy. Adjunct therapy with adrenal corticosteroids is recommended early posttransplant.
Adult Patients in Liver Transplantation: Recommended Dose: 0.1-0.15 mg/kg/day administered in 2 divided daily doses every 12 hrs. Most patients are stable when trough whole blood concentrations are maintained between 5-20 ng/mL. Long-term posttransplant patients often are maintained at low end of this target range.
Administration: The initial dose of Seegraf should be administered no sooner than 6 hrs after transplantation.
Administration/Replacement of Cyclosporine: Seegraf should be administered simultaneously with cyclosporine.
In switching over from cyclosporine to Seegraf, cyclosporine should be stopped for 24 hrs prior to switch over.