Generally well tolerated. Most adverse events are mild to moderate in severity and transient. Nausea and vomiting are commonly observed in the postoperative period at a similar incidence to those found in other inhalation anaesthetics. In addition to nausea and vomiting, other frequent adverse reactions were: Adults:
Hypotension and bradycardia. Children: Agitation and increased cough.
Less frequent adverse reactions associated with sevoflurane administration were: Agitation, somnolence, chills, bradycardia, dizziness, increased salivation, respiratory disorder, hypertension, tachycardia, laryngismus, fever, headache, hypothermia, increased SGOT.
Occasionally reported adverse reactions associated with the administration of sevoflurane includes: Arrhythmias, increased LDH, increased SGPT, hypoxia, apnoea, leukocytosis, ventricular extrasystoles, supraventricular extrasystoles, asthma, confusion, increased creatinine, urinary retention, glycosuria, atrial fibrillation, complete AV block, bigeminy, leucopenia. Allergic reactions eg, rash, urticaria, pruritus, bronchospasm, anaphylactic or anaphylactoid reactions have also been reported. As with all potent inhaled anaesthetics, sevoflurane may cause dose-dependent cardiorespiratory depression.
Convulsions may occur extremely rarely following sevoflurane administration, particularly in children.
There have been very rare reports of pulmonary oedema.