Simeticone: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Flatulence

Adult: 100-250 mg 3 or 4 times daily, or as directed. Dosage recommendation may vary among countries and individual products (refer to specific product guideline).
Child: <2 years weighing <10.9 kg: 20 mg 4 times daily as necessary after meals and at bedtime. Max: 240 mg/24 hours. ≥2 years weighing ≥10.9 kg: 40 mg 4 times daily as necessary after meals and at bedtime. Max: 480 mg/24 hours. Dosage recommendation may vary among countries and individual products (refer to specific product guideline).

Administration

May be taken with or without food. Take after meals & at bedtime for best results.

Special Precautions

Children. Pregnancy and lactation.

Adverse Reactions

Gastrointestinal disorders: Nausea, constipation, mild diarrhoea, regurgitation, vomiting, heartburn.
Immune system disorders: Rarely, hypersensitivity reactions (e.g. rash, facial oedema, pruritus, tongue oedema, respiratory difficulty).

Pregnancy Category (US FDA)

PO: C

Drug Interactions

May diminish the absorption of levothyroxine.

Food Interaction

Avoid carbonated beverage and gas-forming food.

Action

Description: Simeticone, a surface-active substance, is a mixture of liquid dimeticones consisting of finely divided silicon dioxide to increase the defoaming effects of silicone. It lowers the surface tension of the intestinal mucous therefore, disperses and prevents gas pockets in the gastrointestinal system.
Synonym: activated dimeticone; activated dimethicone; simethicone.
Pharmacokinetics:
Absorption: Not absorbed from the gastrointestinal tract.
Excretion: Via faeces as unchanged drug.

Chemical Structure

Storage

Store between 20-25°C. Protect from moisture, light and heat. Oral susp: Do not freeze.

MIMS Class

GIT Regulators, Antiflatulents & Anti-Inflammatories

References

Anon. Simeticone (Simethicone). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 11/05/2021.

Buckingham R (ed). Simeticone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/05/2021.

Dentinox Infant Colic Drops (Dendron Brands Limited). MHRA. https://products.mhra.gov.uk. Accessed 11/05/2021.

Extra Strength Simethicone Antigas 125 mg Capsule, Gelatin Coated (LLS Health LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/05/2021.

Gas-X Extra Strength Tablet, Chewable (GlaxoSmithKline Consumer Healthcare Holdings [US] LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/05/2021.

Gas-X Maximum Strength Softgels (GlaxoSmithKline Consumer Healthcare Holdings [US] LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/05/2021.

Gas-X Ultra Strength Antigas Softgels (GlaxoSmithKline Consumer Healthcare Holdings [US] LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/05/2021.

Gazgo 200 mg Softgel Capsules (Mega Lifesciences Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 11/05/2021.

Infants Gas Relief Suspension/Drops (Cardinal Health). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/05/2021.

Joint Formulary Committee. Simeticone. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/05/2021.

Mylicon Infants Gas Relief Original Emulsion (Infirst Healthcare). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/05/2021.

WindSetlers Capsules (Thornton & Ross Limited). MHRA. https://products.mhra.gov.uk. Accessed 11/05/2021.

Disclaimer: This information is independently developed by MIMS based on Simeticone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com