Coadministration with amiodarone may result in serious symptomatic bradycardia. Use of ZIFAM SOVIR PLUS with amiodarone is not recommended.
P-gp inducers (e.g., rifampin, St. John's wort): May alter concentrations of ledipasvir and sofosbuvir. Use of ZIFAM SOVIR PLUS with P-gp inducers is not recommended.
Frequent monitoring of international normalized ratio (INR) values is recommended in patients receiving warfarin.
Consult the full prescribing information prior to use for potential drug interactions.