Sulbenicillin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV/IM Acute resp tract infections; Susceptible infections 4-6 g/day in divided doses.
Dosage Details
Parenteral
Acute respiratory tract infections, Susceptible infections
Adult: 4-6 g/day, in divided doses by IM, IV inj or infusion.
Contraindications
Hypersensitivity.
Special Precautions
Sodium restricted diet. Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor hepatic, renal and haematological status. Spirochete infections particularly syphilis; prolonged use may lead to suprainfection with penicillin-resistant organisms; avoid intrathecal route.
Adverse Reactions
Pain at the inj site and phloebitis; electrolyte disturbances; dose-dependent coagulation defect; purpura and haemorrhage; hypersensitivity reactions including urticaria; fever; joint pain; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Probenecid may prolong half-life of sulbenicillin. Efficacy may be reduced by tetracyclines.
Lab Interference
May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Action
Description: Sulbenicillin is a broad-spectrum semisynthetic penicillin that has actions and uses similar to those of carbenicillin.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Sulbenicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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