Sultamicillin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Otitis media; Resp tract infections; UTI 375-750 mg twice daily. Uncomplicated gonorrhoea 2.25 g as single dose w/ probenecid.
Dosage Details
Oral
Uncomplicated gonorrhoea
Adult: 2.25 g as single dose, together with 1 g probenecid.

Oral
Otitis media, Respiratory tract infections, Urinary tract infections
Adult: 375-750 mg bid.
Child: <30 kg: 25-50 mg/kg/day in 2 divided doses. ≥30 kg: same as adult dose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity.
Special Precautions
Overgrowth of nonsusceptible organism. Periodic check for organ system dysfunction during prolonged therapy. Neonates, pregnancy, lactation.
Adverse Reactions
Diarrhoea, nausea, vomitting, rashes, pruritus, blood dyscrasias, superinfections, dizziness, dyspnoea.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Concurrent use increases risk of bleeding with warfarin and methotrexate toxicity; decreases efficacy of oestrgen-containing oral contraceptives. Excretion of ampicillin is reduced when used with probencid.
Lab Interference
Interferes with urinary glucose test using cupric sulfate (eg. Benedict's reagent, Clinitest); false increase of urinary protein (in Coomassie brilliant blue method); falsely increase serum albumin concentrations (in bromcresol green procedure); false positive direct antiglobulin (Coombs') test results; false-positive result in iodine-azide spot test (for sulfite oxidase deficiency); false-positive for leucine/isoleucine, phenylalanine, and β-aminoisobutyric acid in paper chromatography studies of urinary amino acids; false decrease in aminoglycoside concentrations; false increase in serum uric acid concentrations (in copper-chelate method). Transient decrease in plasma conc of total conjugated oestriol, oestriol-glucuronide, conjugated oestrione and oestradiol in pregant women.
Action
Description: Sultamicillin inhibits β-lactamases in penicillin-resistant microorganisms and it acts against sensitive organisms during the stage of active multiplication by inhibiting biosynthesis of cell wall mucopeptide.
Storage
Oral:
Otitis media,Respiratory tract infections,Urinary tract infections: Store below 30 °C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Sultamicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Sulbacin
  • Unasyn
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in