Tacalcitol


Concise Prescribing Info
Indications/Uses
Plaque psoriasis.
Dosage/Direction for Use
Adult : Topical 4 mcg/g ointment or lotion: Apply sparingly onto affected area(s) once daily, preferably at bedtime. Max dose: 10 g ointment or 10 mL daily; 280 mcg per week (e.g. 30 mL lotion + 40 g ointment).
Dosage Details
Oral
Plaque psoriasis
Adult: As 4 mcg/g ointment or lotion: Apply sparingly onto affected area(s) once daily, preferably at bedtime. Max dose: 10 g ointment or 10 mL daily; 280 mcg per week (e.g. 30 mL lotion + 40 g ointment).
Contraindications
Hypercalcaemia, Ca metabolism disorder.
Special Precautions
Patient with generalised pustular or erythrodermic exfoliative psoriasis. Renal impairment. Pregnancy and lactation. Combined treatment with UV radiation.
Adverse Reactions
Significant: Hypercalcaemia.
Nervous system disorders: Paraesthesia.
Skin and subcutaneous tissue disorders: Skin irritation, itching, burning, erythema, contact dermatitis.
Patient Counseling Information
Avoid contact with eyes.
MonitoringParameters
Monitor serum Ca level.
Drug Interactions
May increase the risk of hypercalcaemia with thiazide diuretics and vitamin D preparations. Increased therapeutic effect and shorten UV radiation period.
Action
Description: Tacalcitol, a synthetic vitamin D3 derivative, is an antipsoriatic agent. It binds to vitamin D receptors to induce differentiation and inhibits hyper-proliferation of keratinocytes.
Synonym: tacalcitolum.
Pharmacokinetics:
Absorption: 0.5% absorbed through psoriatic skin.
Distribution: Completely bound to plasma proteins.
Excretion: Mainly via urine.
Chemical Structure

Chemical Structure Image
Tacalcitol

Source: National Center for Biotechnology Information. PubChem Database. Tacalcitol, CID=5283734, https://pubchem.ncbi.nlm.nih.gov/compound/Tacalcitol (accessed on Jan. 23, 2020)

Storage
Store below 25°C.
ATC Classification
D05AX04 - tacalcitol ; Belongs to the class of other antipsoriatics for topical use.
References
Anon. Causes of Hypercalcemia. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/05/2018.

Buckingham R (ed). Tacalcitol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/05/2018.

Joint Formulary Committee. Tacalcitol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/05/2018.

Disclaimer: This information is independently developed by MIMS based on Tacalcitol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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