Tamoxifen Ebewe

Tamoxifen Ebewe

tamoxifen

Manufacturer:

EBEWE Pharma

Distributor:

Maxxcare

Marketer:

Mega Lifesciences
Concise Prescribing Info
Contents
Tamoxifen
Indications/Uses
Breast cancer & endometrium carcinoma in women. Adjuvant therapy for women w/ positive axillary node breast cancer. Metastatic breast cancer in men & women.
Dosage/Direction for Use
20 mg daily. Max: 40 mg daily. Patient w/ advanced disease 30 or 40 mg daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Severe thrombocytopenia, leukopenia or hypercalcaemia. Pregnancy.
Special Precautions
Discontinue if atypical hyperplasia develops. Increased incidence of endometrial changes including hyperplasia, polyps & cancer. Patients w/ liver & kidney disease, DM, history of thromboembolic disease, visual disturbances. Perform gynaecological & internal exams prior to & at least 6-mthly intervals during treatment; ophth exam; lung & bone x-ray & liver ultrasound to see possible early metastasis. Contraceptive measures should be taken at least 3 mth after end of therapy. Not recommended during lactation.
Adverse Reactions
Hot flushes, abnormal vag bleeding including menstrual irregularities, vag discharge & pruritus vulvae; fluid retention, nausea, vomiting. Impotence or loss of libido in males. Leukopenia, thrombocytopenia. Ophth disturbances, hypersensitivity reactions.
Drug Interactions
Oestrogen-containing hormone medications may decrease both effects. May increase anticoagulant effect of coumarin-type anticoagulants. May increase bleeding tendency w/ thrombocyte aggregation inhibitors. More frequent thromboembolic events w/ cytotoxic agents. Elevated serum w/ bromocriptine.
ATC Classification
L02BA01 - tamoxifen ; Belongs to the class of anti-estrogens. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Tamoxifen Ebewe tab 20 mg
Packing/Price
30's
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