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Tecavir

Tecavir

entecavir

Manufacturer:

Aristopharma

Distributor:

KTZ
Concise Prescribing Info
Contents
Entecavir monohydrate
Indications/Uses
Chronic hepatitis B virus infection; decompensated cirrhosis.
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Dosage/Direction for Use
Adult >16 yr Not previously treated w/ nucleoside analogues: 0.5 mg once daily. Lamivudine or telbivudine resistant chronic hepatitis B: 1 mg once daily. Renal impairment CrCl ≥50 mL/min 0.5 mg 24 hrly. CrCl 30-<50 mL/min 0.5 mg 48 hrly. CrCl 10-<30 mL/min 0.5 mg 72 hrly. CrCl <10 mL/min, hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) 0.5 mg every 7 days.
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Administration
Should be taken on an empty stomach: Take at least 2 hr before or 2 hr after meals.
Contraindications
Hypersensitivity.
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Special Precautions
Monitor liver function tests 3 mthly; viral & serological markers for hepatitis B 3-6 mthly. Discontinue w/ liver function deterioration, hepatic steatosis, progressive hepatomegaly or unexplained lactic acidosis. Recurrent hepatitis may occur on discontinuation. Renal impairment. Pregnancy & lactation.
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Adverse Reactions
Headache, fatigue, dizziness & nausea.
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Drug Interactions
Mutual increased serum conc w/ drugs reducing renal function or competing for active tubular secretion.
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Storage
View Tecavir storage conditions for details to ensure optimal shelf-life.
Description
View Tecavir description for details of the chemical structure and excipients (inactive components).
Action
View Tecavir mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Antivirals
ATC Classification
J05AF10 - entecavir ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Tecavir FC tab 0.5 mg
Packing/Price
1 × 10's
Form
Tecavir FC tab 1 mg
Packing/Price
1 × 10's
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