Tetryzoline


Concise Prescribing Info
Indications/Uses
Conjunctival decongestant.
Dosage/Direction for Use
Adult : Ophthalmic Instill 1-2 drops into the affected eye(s) 4 times daily.
Dosage Details
Ophthalmic
Conjunctival decongestant
Adult: As 0.05% tetryzoline hydrochloride solution: Instill 1-2 drops into the affected eye(s) 4 times daily.
Special Precautions
Patient with CV disease (e.g. hypertension, coronary artery disease), diabetes, narrow-angle glaucoma, hyperthyroidism. Pregnancy and lactation.
Adverse Reactions
Cardiac disorders: Palpitations, tachycardia.
Eye disorders: Blurred vision, eye irritation, mydriasis, rebound congestion (prolonged use).
General disorders and administration site conditions: Weakness, sweating.
Nervous system disorders: Headache, tremor.
Vascular disorders: Hypertension.
Patient Counseling Information
Remove contact lenses prior to ophthalmic administration and reinsert after 10 minutes.
Action
Description: Tetryzoline is an α-adrenergic receptor agonist. The exact mechanism of action has not been fully elucidated, but it is believed to cause vasoconstriction by stimulating arterioles of the conjunctiva.
Synonym: tetrahydrozoline.
Onset: Within few minutes.
Duration: 4-8 hours.
Chemical Structure

Chemical Structure Image
Tetryzoline

Source: National Center for Biotechnology Information. PubChem Database. Tetrahydrozoline, CID=5419, https://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrozoline (accessed on Jan. 23, 2020)

Storage
Store between 15-25°C.
ATC Classification
S01GA02 - tetryzoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
References
Anon. Tetrahydrozoline (Ophthalmic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/04/2018.

Anon. Tetrahydrozoline. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com/. Accessed 10/04/2018.

Buckingham R (ed). Tetryzoline Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/04/2018.

CVS Redness Relief Original Solution/drops (CVS Pharmacy, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 12/04/2018.

Visine Original Redness Relief Solution/drops (Johnson & Johnson Consumer Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/04/2018.

Disclaimer: This information is independently developed by MIMS based on Tetryzoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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