Tolnaftate


Concise Prescribing Info
Indications/Uses
Superficial dermatophyte infections.
Dosage/Direction for Use
Adult : Topical As 1% gel/soln/powd/cream: Apply a thin layer to the affected area(s) bid. As powder/liq spray: Spray a thin layer to the affected area(s) bid. Treatment duration: 2 wk (tinea cruris); 4 wk (tinea corporis, tinea pedis).
Dosage Details
Topical/Cutaneous
Superficial dermatophyte infections
Adult: As 1% gel/soln/powd/cream: Apply a thin layer to the affected area(s) bid. As powder/liq spray: Spray a thin layer to the affected area(s) bid. Treatment duration: 2 wk (tinea cruris); 4 wk (tinea corporis, tinea pedis).
Child: 2 yr Same as adult dose.
Contraindications
Hypersensitivity.
Special Precautions
Not intended for use for nail or scalp infections.
Adverse Reactions
Dermatologic: Irritation, contact dermatitis, pruritus, stinging.
Patient Counseling Information
Avoid contact w/ eyes.
Action
Description: Tolnaftate is a synthetic thiocarbamate antifungal agent which inhibits the growth of dermatophytes (e.g. Epidermophyton, Micosporum, Trichophyton spp., Malassezia furfur) by distorting the hyphae and stopping mycelial growth in susceptible fungi. It is inactive against Candida spp. or bacteria.
Onset: 24-72 hr.
Chemical Structure

Chemical Structure Image
Tolnaftate

Source: National Center for Biotechnology Information. PubChem Database. Tolnaftate, CID=5510, https://pubchem.ncbi.nlm.nih.gov/compound/Tolnaftate (accessed on Jan. 23, 2020)

Storage
Store between 20-25°C.
ATC Classification
D01AE18 - tolnaftate ; Belongs to the class of other antifungals for topical use.
References
Anon. Tolnaftate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/10/2017.

Buckingham R (ed). Tolnaftate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/10/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Tolnaftate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/10/2017.

Tinactin Cream (Bayer Healthcare LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 26/10/2017.

Tolnaftate Gel (Alva-Amco Pharmacal Companies, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 26/10/2017.

Tolnaftate Liquid Spray (Topco Associates LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 26/10/2017.

Tolnaftate Powder Spray (CVS Pharmacy). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 26/10/2017.

Tolnaftate Solution (Perrigo New York Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 26/10/2017.

Disclaimer: This information is independently developed by MIMS based on Tolnaftate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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