Toloxatone


Concise Prescribing Info
Indications/Uses
Depression.
Dosage/Direction for Use
Adult : PO 200 mg 3 times/day.
Dosage Details
Oral
Depression
Adult: 200 mg tid.
Contraindications
Pregnancy, lactation.
Special Precautions
Stop toloxatone 6 hr before general anaesthesia. Monitor BP at the start of treatment.
Adverse Reactions
Dysuria, nausea, constipation, vertigo, insomnia.
Potentially Fatal: Fulminant hepatitis.
Drug Interactions
Increased risk of serotonin syndrome with SSRI, TCA. Increased BP with sympathomimetics. Increased concentration of triptans.
Potentially Fatal: Increased risk of hypertension and CNS excitation when given with MAOI, wait for 15-20 days after end of MAOI therapy before starting toloxatone.
Food Interaction
Increased BP with large amounts of tyramine-rich food.
Action
Description: Toloxatone is a reversible inhibitor of monoamine oxidase type-A (RIMA).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Toloxatone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in