tranexamic acid


Pacific Pharma (Korea)


AA Medical
Concise Prescribing Info
Tranexamic acid
Hemorrhagic complications in association w/ general fibrinolysis (leukemia, purpura, aplastic anemia, pre- & post-op hemorrhage), & local fibrinolysis (pneumorrhagia, nephrorrhagia, prostatectomy, pre- & post-op hemorrhage).
Dosage/Direction for Use
IV/IM 500 mg by slow IV inj. Adult 250-500 mg in 1 or 2 divided doses. Intra/post-op bleeding 500-1,000 mg IV or 500-2,500 by IV instillation once daily.
Hypersensitivity. Patients receiving thrombin; history or risk of thrombosis. Should not be added to blood for transfusion, or to inj containing penicillin.
Special Precautions
May cause side effects due to glass fraction mixed. Patients w/ thrombus (cerebral thrombosis, MI, thrombophlebitis) or risk of thrombosis; consumption coagulopathy; should be concomitantly used w/ heparin. Pulmonary thromboembolism may occur when moving the bed or stopping the pressure in patients lying in bed after surgery, or w/ pressure hemostasis treatment. Restrict treatment of disseminated intravascular coagulation (DIC) to those w/ predominant activation of the fibrinolytic system w/ acute severe bleeding. Do not administer in DIC w/ predominant activation of the coagulation system. Consider use in DIC only when appropriate haematological lab facilities & expertise are available. Risk of drug accumulation in renal insufficiency. Use w/ caution in pregnancy & lactation. Caution in use in elderly.
Adverse Reactions
Shock. Temporary disturbance of color vision; urinary tract obstructions in patients w/ large bleeding from upper urinary tract; nausea, vomiting, diarrhea.
Drug Interactions
Increased thrombus formation w/ thrombin, possible thrombosis w/ drugs w/ actions on hemostasis or hemocoagulase, Batroxobin. May enhance coagulation on strong fibrinolytic activity site eg, mouth w/ coagulation factors eg, Eptacog α.
MIMS Class
ATC Classification
B02AA02 - tranexamic acid ; Belongs to the class of amino acid antifibrinolytics. Used in the treatment of hemorrhage.
Tranexamin inj 500 mg
5 mL x 10 × 1's
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