May cause side effects due to glass fraction mixed. Patients w/ thrombus (cerebral thrombosis, MI, thrombophlebitis) or risk of thrombosis; consumption coagulopathy; should be concomitantly used w/ heparin. Pulmonary thromboembolism may occur when moving the bed or stopping the pressure in patients lying in bed after surgery, or w/ pressure hemostasis treatment. Restrict treatment of disseminated intravascular coagulation (DIC) to those w/ predominant activation of the fibrinolytic system w/ acute severe bleeding. Do not administer in DIC w/ predominant activation of the coagulation system. Consider use in DIC only when appropriate haematological lab facilities & expertise are available. Risk of drug accumulation in renal insufficiency. Use w/ caution in pregnancy & lactation. Caution in use in elderly.