IV/IM 500 mg by slow IV inj. Adult 250-500 mg in 1 or 2 divided doses. Intra/post-op bleeding 500-1,000 mg IV or 500-2,500 by IV instillation once daily.
Hypersensitivity. Patients receiving thrombin; history or risk of thrombosis. Should not be added to blood for transfusion, or to inj containing penicillin.
May cause side effects due to glass fraction mixed. Patients w/ thrombus (cerebral thrombosis, MI, thrombophlebitis) or risk of thrombosis; consumption coagulopathy; should be concomitantly used w/ heparin. Pulmonary thromboembolism may occur when moving the bed or stopping the pressure in patients lying in bed after surgery, or w/ pressure hemostasis treatment. Restrict treatment of disseminated intravascular coagulation (DIC) to those w/ predominant activation of the fibrinolytic system w/ acute severe bleeding. Do not administer in DIC w/ predominant activation of the coagulation system. Consider use in DIC only when appropriate haematological lab facilities & expertise are available. Risk of drug accumulation in renal insufficiency. Use w/ caution in pregnancy & lactation. Caution in use in elderly.
Shock. Temporary disturbance of color vision; urinary tract obstructions in patients w/ large bleeding from upper urinary tract; nausea, vomiting, diarrhea.
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