Careful Administration: Transamin should be administered with care in the following patients: Patients with thrombosis (eg, cerebral thrombosis, myocardial infarction or thrombophlebitis) and patients at risk of thrombosis. Transamin may stabilize thrombosis.
Patients with consumption coagulopathy (use concomitantly with heparin). Transamin may stabilize thrombosis.
Post-operative, recumbent ridden patients and patients undergoing astriction. Venous thrombosis is likely to occur in these patients and Transamin may stabilize thrombosis. Pulmonary embolism has been reported in association with resolution of recumbency or removal of astriction.
Patients with renal failure. Blood concentration may increase.
Patients with a history of hypersensitivity to any of the component of Transamin.
Other Precautions: Retinal degeneration has been reported with tranexamic acid in dogs after long-term, high-dose administration.
Use in Pregnancy & Lactation: Pregnancy Category: B. No safety information.
Use in the Elderly: Since elderly patients often have reduced physiological function, careful supervision and measures eg, reducing the dose are recommended.