Adult: Each tab/cap contains triamterene 37.5 mg and hydrochlorothiazide 25 mg: 1-2 tab/cap once daily. Each tab contains triamterene 50 mg and hydrochlorothiazide 25 mg: Initially, 1 tab daily after the morning meal, adjust thereafter according to response. Max: 4 tab daily. Each tab/cap contains triamterene 75 mg and hydrochlorothiazide 50 mg: 1 tab/cap daily.
Adult: Each tab/cap contains triamterene 37.5 mg and hydrochlorothiazide 25 mg: 1-2 tab/cap once daily. Each tab contains triamterene 50 mg and hydrochlorothiazide 25 mg: Initially, 1 tab bid. Maintenance: 1 tab daily or 2 tab on alternate days. Max: 4 tab daily. Each tab/cap contains triamterene 75 mg and hydrochlorothiazide 50 mg: 1 tab/cap daily.
Should be taken with food.
Hyperkalaemia (≥5.5 mEq/L), hypercalcaemia, diabetic ketoacidosis, Addison’s disease, progressive renal failure, increasing hepatic dysfunction. Concomitant use w/ K supplements, other K-conserving drugs, including ACE inhibitors.
Patients w/ prediabetes or DM, diabetic nephropathy, predisposition to gout, history of renal lithiasis. Hepatic or renal impairment. Pregnancy and lactation.
This drug may cause a blue fluorescence of the urine under certain light conditions.
Monitor BUN, BP, serum K levels and other electrolytes, creatinine, LFTs, signs of hyperkalaemia.
Symptoms: Electrolyte imbalance, nausea, vomiting, weakness, polyuria, lassitude, fever, flushed face, hyperactive deep tendon reflexes, hypotension, cardiac arrhythmias. Management: Induce immediate evacuation through emesis or gastric lavage. Pressor agents e.g. norepinephrine may be given in case of hypotension.
May reduce the renal clearance of lithium. May antagonise diuretic effect w/ NSAIDs, corticosteroids, oestrogens, combined OCs. Enhanced effect w/ other hypotensive agents, baclofen, tizanidine. May decrease arterial responsiveness to norepinephrine. Increases responsiveness to tubocurarine. Risk of acute renal failure w/ indometacin. Increased risk of hyperkalaemia w/ reboxetine, tacrolimus. Increased risk of ototoxicity and nephrotoxicity w/ platinum compounds (e.g. cisplatin). Potentially Fatal: Increased risk of hyperkalaemia w/ K supplements, other K-conserving drugs, including ACE inhibitors.
Interferes w/ some thyroid and parathyroid function tests, bioassay of folic acid and measurement of quinidine.
Description: Triamterene directly inhibits the exchange of Na for K and hydrogen in the distal renal tubule. Hydrochlorothiazide increases the excretion of Na and Cl ions, and consequently of water, by reducing electrolyte reabsorption from the renal tubules. Onset: W/in 1 hr. Pharmacokinetics: Absorption: Incompletely but fairly rapidly absorbed from the GI tract. Triamterene: Bioavailability: Approx 50%. Time to peak plasma concentration: W/in 1 hr. Hydrochlorothiazide: Bioavailability: Approx 65-70%. Time to peak plasma concentration: Approx 2 hr. Distribution: Triamterene: Plasma protein binding: Approx 67%. Hydrochlorothiazide: Crosses the placenta and enters breast milk. Metabolism: Triamterene: Metabolised to 6-p-hydroxytriamterene and its sulfate conjugate. Excretion: Triamterene: Via urine (10-88%); bile (variable amounts). Plasma half-life: Approx 2 hr. Hydrochlorothiazide: Via urine as unchanged drug. Elimination half-life: Approx 3-6 hr.
C03EA01 - hydrochlorothiazide and potassium-sparing agents ; Belongs to the class of low-ceiling diuretics in combination with potassium-sparing agents. Used as diuretics.
Anon. Hydrochlorothiazide and Triamterene. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/03/2016.Buckingham R (ed). Hydrochlorothiazide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/03/2016.Buckingham R (ed). Triamterene. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/03/2016.McEvoy GK, Snow EK, Miller J et al (eds). Triamterene. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 10/03/2016.Triamterene and Hydrochlorothiazide Tablet (Actavis Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/03/2016.