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Indications and Dosage
Oral
Irritable bowel syndrome Adult: 100-200 mg tid.
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Administration
May be taken with or without food.
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Reconstitution
Reconstitute the granules in the provided bottle by adding water up to the designated mark then shake the bottle to mix. Refer to specific product guidelines for appropriate instructions on reconstitution.
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Significant: CNS depression.
Nervous system disorders: Presyncope/syncope. Skin and subcutaneous tissue disorders: Rash. Psychiatric disorders: Mood change. |
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Patient Counseling Information
This drug may impair physical and mental abilities, if affected, do not drive or operate machinery.
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Action
Description: Trimebutine is a gastrointestinal motility modifier. It promotes intestinal motility by triggering phase-III waves produced by the migrating motor complex, it also inhibits motility in the occurrence of prior stimulation.
Pharmacokinetics: Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-2 hours. Excretion: Mainly via urine (70%); faeces (5-12%). Elimination half-life: Approx 10-12 hours. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5573, Trimebutine. https://pubchem.ncbi.nlm.nih.gov/compound/Trimebutine. Accessed July 28, 2021. |
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Storage
Store below 30°C.
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ATC Classification
A03AA05 - trimebutine ; Belongs to the class of synthetic anticholinergics, esters with tertiary amino group. Used in the treatment of functional bowel disorders.
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References
Anon. Trimebutine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/07/2021. Buckingham R (ed). Trimebutine Maleate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/07/2021.
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