Trinpac

Trinpac

Manufacturer:

Pacific Pharma (Korea)

Distributor:

AA Medical
Full Prescribing Info
Contents
Tretinoin, erythromycin.
Description
Each 1 g contains Tretinoin 0.25 mg, Erythromycin 40 mg (potency).
Excipients/Inactive Ingredients: Hydroxypropylmethylcellulose, Propylene glycol, Butylhydroxytoluene, Ethanol.
Indications/Uses
Acne vulgaris: Acne polymorphic predominant microcyst or inflammation; Acne monomorphic papulopustular.
Acne conglobation: In association with others special therapy.
Other acne: Acne caused by using corticoids, Vitamin B12, Vitamin D, isoniazide, barbiturics, iode, brom.
Dosage/Direction for Use
Generally, apply to affected area once a day in the evening after the skin is thoroughly washed and patted dry.
Excessive application of this drug may result in the induction of irritation response in skin.
The hands should be washed after application.
Rub a little amount of this drug until penetrated in skin.
Contraindications
Patients with hypersensitivity of this drug or macrolides.
Patients with family history of skin epithelioma.
Patients with eczema, bone fraction or excoriation.
Patients with sunburn should be advised not to use the product until fully recovered.
Pregnant women, nursing mother and women suspected of being pregnant should be advised not to use the product.
Special Precautions
Since studies in mouse suggest that this drug may accelerate the development of skin tumor by sunlight. It is recommended to avoid exposure to sunlight during medication of this drug. Patients being exposed to sun should avoid using this drug yesterday, today, and tomorrow.
During early therapy, apply after using limited area of skin.
To avoid bacterial resistance, notify sensitivity and medicate minimum period required.
Make an observation sufficiently, since sensitization may occur. If sensitized symptoms (itching, redness, swelling, papula, phlyctenule etc) develop, discontinue the application.
Bacterial resistance to antibiotics may occur in case of using for a long term. Discontinue application and take proper treatment.
Use In Pregnancy & Lactation
Pregnant women: Oral tretinoin has induced abnormity of skeleton in animals.
There are no adequate studies in human. Tretinoin should not be used during first 3 months of pregnancy and safety after the period has not yet been established.
Nursing mother: Since safety in nursing mother has not yet been established, apply if it is truly necessary.
Adverse Reactions
Skin dryness, pruritus, desquamation, erythema, redness, edema, herpes or incrustation may occur by difference among individuals. In this case, discontinue or control use of this drug.
Hyper or hypo pigmentation has been reported in case of using product continuously.
Contact dermatitis has been rarely reported.
Sensitivity to sunlight may be increased.
Weather extremes, such as wind or cold may irritate to patients.
Since eruption rarely occur, medication should be discontinued in this case.
Inform the doctor or pharmacist in case of any adverse reactions related to drug use.
Drug Interactions
Particulate caution should be exercised in using sulfur, resorcinol, benzoyl peroxide, salicylic acid, clindamycin or lincomycin with this drug, because of possible interaction.
Patients using keratolytics should apply this drug after effect of preparations subside.
Medicated or abrasive soaps and cleaners, cosmetics with a strong drying effect, preparations with a high concentration of alcohol, astringents or lime should be used with care because of possible interaction with this drug.
Caution For Usage
Precaution for application: It should be kept away from the eyes, angles of nose, mouth, and mucous membranes.
This drug should not be accumulated in wrinkled area of skin.
This drug should be avoided to contacting to clothes, etc.
Storage
In a light-resistance airtight container at room temp.
Shelf-Life: 36 months from manufacturing date.
ATC Classification
D10AD51 - tretinoin, combinations ; Belongs to the class of topical retinoid preparations. Used in the treatment of acne.
Presentation/Packing
Topical gel 10 g x 1's.
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