Contraindicated: Aliskiren (in diabetic or impaired renal patients), extracorporeal treatments, sacubitril/valsartan. Not recommended: Lithium, aliskiren (in patients other than diabetic or impaired renal patients), concomitant therapy w/ ACE inhibitors & angiotensin-receptor blocker, estramustine, K-sparing drugs (eg, triamterene, amiloride), K salts, co-trimoxazole (trimethoprim/sulfamethoxazole), dantrolene (infusion), grapefruit or grapefruit juice. Special care: Baclofen, NSAIDs (including acetylsalicylic acid at high doses), antidiabetic agents (insulin, hypoglycaemic agents), non-K-sparing & K-sparing (eplerenone, spironolactone) diuretics, racecadotril, mTOR inhibitors (eg, sirolimus, everolimus, temsirolimus), Torsades de pointes-inducing drugs, amphotericin B (IV route), glucocorticoids & mineralocorticoids (systemic route), tetracosactide, stimulant laxatives, cardiac glycosides, allopurinol, CYP3A4 inhibitors. To be taken into consideration: Imipramine-like antidepressants (tricyclics), neuroleptics, other antihypertensives & vasodilatators, tetracosactide, allopurinol, cytostatic or immunosuppressives, systemic corticosteroids or procainamide, anaesth, diuretics (thiazide or loop diuretics), gliptines (linagliptine, saxagliptine, sitagliptine, vildagliptine), sympathomimetics, gold, metformin, iodinated contrast media, Ca (salts), ciclosporine, atorvastatin, digoxin, warfarin, tacrolimus, simvastatin.