Pharmacology: Mechanism of Action: Hyperosmotic, Saline: produces osmotic effect primarily in small intestine by drawing water into the intestinal lumen. Fluid accumulation produces distention, which in turn promotes increased peristalsis and bowel evacuation. During the use of saline laxatives, the release of cholecystokinin from the intestinal mucosa may enhance the laxative effect.
Note: Knowledge of many specifics of the mechanisms of action is limited. The determination of influence of factors such as cyclic-AMP, electrolyte transportation, hormones, and enzymes may change such currently accepted mechanisms.
Pharmacokinetics: Absorption: Rectal (poor).
Onset of Action: 2-5 minutes.
Type of Stool Formed: Watery stool (with high doses).
Elimination (of absorbed doses): Renal.