Sodium biphosphate, Sodium phosphate.
Each 118 mL (delivered dose) contains: Sodium biphosphate 19 g and Sodium phosphate 7 g.
Pharmacology: Mechanism of Action: Hyperosmotic, Saline: produces osmotic effect primarily in small intestine by drawing water into the intestinal lumen. Fluid accumulation produces distention, which in turn promotes increased peristalsis and bowel evacuation. During the use of saline laxatives, the release of cholecystokinin from the intestinal mucosa may enhance the laxative effect.
Note: Knowledge of many specifics of the mechanisms of action is limited. The determination of influence of factors such as cyclic-AMP, electrolyte transportation, hormones, and enzymes may change such currently accepted mechanisms.
Pharmacokinetics: Absorption: Rectal (poor).
Onset of Action: 2-5 minutes.
Type of Stool Formed: Watery stool (with high doses).
Elimination (of absorbed doses): Renal.
Laxatives promote defecation and used in the treatment of constipation and for bowel evacuation before investigational procedures such as endoscopy or radiological examination or before surgery.
Adult: one bottle.
1. Pull to remove the cap from the tip.
2. Slowly insert to the rectum.
3. Squeeze the bottle until it is empty.
4. Remove the tip carefully from the rectum, wait until urge to evacuate (usually 2 to 5 minutes).
Or as prescribed by the physician.
Proper use of this medication: Proper administration technique; reading patient directions carefully.
Lubrication of anus with petroleum jelly before insertion of enema applicator and careful insertion to prevent damage to rectal wall.
Appendicitis or symptoms of; Bleeding, rectal, undiagnosed; Congestive heart failure or hypertension; Intestinal obstruction; Dehydration (may be aggravated by repeated use); Renal function impairment.
Do not use when nausea, vomiting or abdominal pain are present.
Do not use laxatives: if symptoms of appendicitis are present; more often than recommended; unnecessarily for example, for cold, as tonic, to clean system; because bowel movement is missed 1 or 2 days.
Check with physician if sudden change in bowel habit persists beyond 2 weeks.
Avoid laxative habit: overuse or extended use may cause dependence for bowel function.
Use in pregnancy: Sodium-containing preparations may promote sodium retention with resultant edema.
Use in children: Laxatives should not be given to young children (up to 6 years) unless prescribed by a physician. Since children are not usually able to describe their symptoms precisely, proper diagnosis should precede the use of laxative. This will avoid the complication of an existing condition (eg, appendicitis) or the appearance of more severe side effects.
Weakness, excessive perspiration, shock, seizures and/or coma may occur in children with the use of rectal solutions due to water intoxication or dilutional hyponatremia.
Use in elderly: Weakness, excessive perspiration, shock, seizures and/or coma may occur in geriatrics with the use of rectal solutions due to water intoxication or dilutional hyponatremia.
Pregnancy: Sodium-containing preparations may promote sodium retention with resultant edema.
Incidence less frequent: Rectal irritation (rectal bleeding, blistering, burning, itching or pain).
Incidence rare: Electrolyte imbalance (confusion, irregular heartbeat, muscle cramps, unusual tiredness or weakness) due to acute overdosage or chronic misuse.
Diuretics, potassium-sparing or potassium supplements: chronic use or overuse of laxatives may reduce serum potassium concentrations by promoting excessive potassium loss from the intestinal tract; may interfere with potassium-retaining effects of potassium-sparing diuretics.
Store at temperature between 23-35°C.
A06AG01 - sodium phosphate ; Belongs to the class of enemas. Used in the treatment of constipation.
Enema (squeezable plastic bottle) 133 mL x 1's.