Vaccine, DTP-HIB-POL


Concise Prescribing Info
Dosage Details
Intramuscular
Active immunisation against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenzae type B
Child: ≥2 months to <5 years As primary immunisation: 2-3 doses of 0.5 mL to be given at least 1-month interval via deep inj into the anterolateral muscles of the thigh or the deltoid muscles of the upper arm. As booster immunisation: 0.5 mL at least 6 months after last dose. Refer to literature as dosage may vary with brand and local guidelines.
Contraindications
Hypersensitivity. History of encephalopathy within 7 days with pertussis vaccine. Progressive neurological disorder (e.g. infantile spasms, uncontrolled epilepsy, or progressive encephalopathy).
Special Precautions
Patient with family history of febrile convulsions, sudden infant death syndrome (SIDS); Guillain-Barre syndrome, ≥40.5°C temperature, hypotonic-hyporesponsive episode or crying for ≥3 hours within 48 hours or seizures within 3 days with pertussis vaccine; seizures, immunosuppression, severe febrile illness, bleeding disorder (e.g. thrombocytopenia).
Adverse Reactions
Significant: Fever (≥40.5°C temperature), hypotonic-hyporesponsive episode, inconsolable crying, irritability, seizures, syncope, Guillain-Barre syndrome, brachial neuritis; apnoea (premature infants).
Gastrointestinal disorders: Nausea, vomiting, diarrhea.
General disorders and administration site conditions: Asthenia, fatigue, malaise, inj site reactions (e.g. tenderness, pain, oedema, erythema).
Metabolism and nutrition disorders: Appetite loss.
Nervous system disorders: Somnolence.
Psychiatric disorders: Restlessness.
Potentially Fatal: Hypersensitivity or anaphylaxis reactions.
MonitoringParameters
Monitor for signs of syncope for 15 minutes after injection.
Drug Interactions
Decrease effect with immunosuppressive agents (e.g. corticosteroids, antimetabolites).
Lab Interference
May interfere with urine antigen detection for Haemophilus influenzae type B infection for a week.
Action
Description: DTP-Hib-POL vaccine, a combination of diphtheria and tetanus toxoids and acellular pertussis, Haemophilus influenzae type B conjugate and inactivated poliovirus, promotes immunity against diphtheria, tetanus, pertussis, Haemophilus influenzae type B infection and poliomyelitis.
Storage
Store between 2-8°C. Do not freeze.
Any unused portion should be disposed of in accordance with local requirements.
ATC Classification
J07CA06 - diphtheria-haemophilus influenzae B-pertussis-poliomyelitis-tetanus ; Belongs to the class of combined bacterial and viral vaccines.
References
Anon. Diphtheria and Tetanus Toxoids, Acellular Pertussis, Poliovirus and Haemophilus b Conjugate Vaccine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/07/2018.

Buckingham R (ed). Diphtheria, Tetanus, Pertussis, Poliomyelitis, and Haemophilus Influenzae Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/07/2018.

Joint Formulary Committee. Diphtheria with Haemophilus Influenzae Type B Vaccine, Pertussis, Poliomyelitis and Tetanus. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/07/2018.

Pentacel (Sanofi Pasteur, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 18/07/2018.

Disclaimer: This information is independently developed by MIMS based on Vaccine, DTP-HIB-POL from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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