Adult 2-4 g every 12 hr in equally divided doses. Severe or refractory infections Dose may be increased up to 8 g. Max dose of sulbactam: 4 g daily. Renal dysfunction: CrCl 15-30 mL/min Max of 1 g sulbactam every 12 hr (max dose of sulbactam: 2 g daily); CrCl <15 mL/min Max of 500 mg sulbactam every 12 hr (max dose of sulbactam: 1 g daily). Childn 40-80 mg/kg/day every 6-12 hr in equally divided doses. Serious or refractory infections Dose may be increased up to 160 mg/kg/day in 2-4 equally divided doses. Neonate in the 1st wk of life Max of 80 mg/kg/day every 12 hr.
Flushing, sweating, headache & tachycardia w/ alcohol during & as late as the 5th day after cefoperazone administration; false +ve reaction for glucose in the urine w/ Benedict's or Fehling's soln. Incompatible w/ aminoglycosides, Lactated Ringer's soln & lidocaine.
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
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