Vaxcel Cefobactam

Vaxcel Cefobactam

cefoperazone + sulbactam




Fair Deal
Concise Prescribing Info
Cefoperazone Na (equiv to cefoperazone 500 mg), sulbactam Na (equiv to sulbactam 500 mg)
Upper & lower resp tract, bone & joint, skin & soft tissue infections; UTI; peritonitis, cholecystitis, cholangitis & other intra-abdominal infections; septicemia; meningitis; pelvic inflammatory disease, endometritis, gonorrhea & other genital tract infections.
Dosage/Direction for Use
Adult 2-4 g every 12 hr in equally divided doses. Severe or refractory infections Dose may be increased up to 8 g. Max dose of sulbactam: 4 g daily. Renal dysfunction: CrCl 15-30 mL/min Max of 1 g sulbactam every 12 hr (max dose of sulbactam: 2 g daily); CrCl <15 mL/min Max of 500 mg sulbactam every 12 hr (max dose of sulbactam: 1 g daily). Childn 40-80 mg/kg/day every 6-12 hr in equally divided doses. Serious or refractory infections Dose may be increased up to 160 mg/kg/day in 2-4 equally divided doses. Neonate in the 1st wk of life Max of 80 mg/kg/day every 12 hr.
Allergy to penicillins, sulbactam, cefoperazone & any of the cephalosporins.
Special Precautions
Serious & occasionally fatal hypersensitivity reactions in patients receiving β-lactam or cephalosporin therapy. Monitor cefoperazone serum conc & adjust dose in patients w/ hepatic dysfunction & concomitant renal impairment. Vit K deficiency in patients w/ poor diet, malabsorption states (eg, cystic fibrosis) & those on prolonged IV alimentation regimens. Pregnancy & lactation. Premature infants & neonates.
Adverse Reactions
Diarrhea/loose stools, nausea, vomiting; maculopapular rash, urticaria; slight decreases in neutrophils, reversible neutropenia (prolonged use), +ve direct Coombs' test, decreased Hb or hematocrit, transient eosinophilia, thrombocytopenia, hypoprothrombinemia; headache, fever, inj pain & chills; transient elevation of liver function tests, SGOT, SGPT, alkaline phosphatase & bilirubin levels; transient pain; anaphylactoid reactions (including shock); hypotension; pseudomembranous colitis; pruritus, Stevens-Johnson syndrome; leucopenia; hematuria.
Drug Interactions
Flushing, sweating, headache & tachycardia w/ alcohol during & as late as the 5th day after cefoperazone administration; false +ve reaction for glucose in the urine w/ Benedict's or Fehling's soln. Incompatible w/ aminoglycosides, Lactated Ringer's soln & lidocaine.
MIMS Class
ATC Classification
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Vaxcel Cefobactam powd for inj 1 g
10 × 1's
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