5,000-10,000 IU 4 hrly by bolus inj or continuous infusion. SC
10,000 IU 8 hrly after an initial IV bolus inj of 5,000 IU. Low-dose heparin prophylaxis
5,000 IU in 0.2 mL SC, 2-6 hr pre-op & 8-12 hrly post-op for 10-14 days or until patient is mobile, whichever is longer. MI
5,000 IU SC 12 hrly beginning during 12 hr following the 1st sign of MI. Open heart surgery
Operations <2 hr: 120 IU/kg/hr. Operations of longer duration: Give 1 1/2 times the dose. 2,000 IU is needed for each 450 mL of blood used. Perioperative prophylaxis 10-14 days to 6 wk. Elderly
Reduce dose in women.