Vitamin E


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Vit E deficicency 40-50 mg/day of d-α tocopherol. Supplementation in cystic fibrosis 100-200 mg/day of dl-α-tocoferil acetate or 67-135 mg/day of d-α-tocopherol. Abetalipoproteinaemia 50-100 mg/kg/day of dl-α-tocoferil acetate or about 33-67 mg/kg/day of d-α-tocopherol.
Dosage Details
Oral
Vitamin E deficiency
Adult: 40-50 mg of d-α tocopherol daily.
Child: Neonate: 10 mg/kg once daily; 1 mth-18 yr: 2-10 mg/kg/day, up to 20 mg/kg.

Oral
Abetalipoproteinaemia
Adult: 50-100 mg/kg daily of dl-α-tocoferil acetate or about 33-67 mg/kg daily of d-α-tocopherol.
Child: Neonate: 100 mg/kg once daily; 1 mth-18 yr: 50-100 mg/kg once daily.

Oral
Supplementation in cystic fibrosis
Adult: 100-200 mg daily of dl-α-tocoferil acetate or 67-135 mg daily of d-α-tocopherol.
Child: As α- tocopheryl acetate: 1 mth-1 yr 50 mg once daily; 1-12 yr 100 mg once daily; 12-18 yr 200 mg once daily. Dose to be adjusted as needed.
Administration
Should be taken with food.
Adverse Reactions
Hypertension; myopathy; thrombophloebitis; fatigue, weakness, nausea, headache, dizziness, blurred vision, flatulence, diarrhoea, abdominal pain. Topical: Contact dermatitis.
Drug Interactions
Colestyramine, colestipol, and orlistat may interfere with vitamin E absorption. High doses of vitamin E potentiates the anticoagulant action of warfarin. Large doses of vitamin E may impair response to iron supplementation.
Action
Description: Vitamin E is a general term used to refer to a large number of natural or synthetic compounds. Tocopherols are the most common compounds, of which alpha tocopherols are the most active and widely distributed in nature. Alpha tocopherols occur naturally in the d optical isomer form and is more active than the synthetic racemic dl form. d-α-tocopheryl acetate is the acetate ester of natural source d-α-tocopherol. Other naturally occurring tocopherols e.g. beta, gamma, and delta tocopherols are not used clinically. Tocotrienols are another group of compounds with vitamin E activity. Vitamin E, a fat soluble vitamin, reacts with free radicals and protects RBCs against haemolysis and polysaturated fatty acids in membranes against free radical attack.
Pharmacokinetics:
Absorption: 20-80% (oral). Absorption depends on the presence of bile and on normal pancreatic function; decrease with increasing dose.
Distribution: Enters blood via the chylomicrons in the lymph; bound to β-lipoproteins. Widely distributed to all tissues. Stored in adipose tissue. Enters breast milk but crosses the placenta poorly.
Metabolism: Hepatic; converted to glucuronides of tocopheronic acid and its γ-lactone.
Excretion: Excreted mainly via bile into faeces and some into urine.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Vitamin E from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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