Anticoagulant-induced prothrombin deficiency. Prophylaxis & therapy of hemorrhagic disease of the newborn. Hypoprothrombinemia due to antibacterial therapy; secondary to factors limiting absorption or synthesis of vit K, eg, obstructive jaundice, biliary fistula, sprue, ulcerative colitis, celiac disease, intestinal resection, cystic fibrosis of the pancreas, & regional enteritis; drug-induced due to interference w/ vit K metabolism eg, salicylates.
SC/IMAdultAnticoagulant-induced prothrombin deficiency 2.5-10 mg or up to 25 mg (rarely 50 mg). Hypoprothrombinemia due to other causes 2.5 mg to ≥25 mg (rarely up to 50 mg). Newborn Hemorrhagic disease of newborn Prophylaxis: 0.5-1 mg IM w/in 1 hr of birth. Treatment: 1 mg SC or IM (higher doses may be necessary if the mother has been receiving oral anticoagulants).
Severe reactions resembling hypersensitivity or anaphylaxis, including fatalities may occur during & immediately after IV inj & following IM administration; avoid rapid infusion.
Adverse Reactions
Transient flushing sensations & peculiar sensations of taste. Pain, swelling, tenderness at the inj site. Anaphylactoid reaction. Erythematous, indurated, pruritic plaques that may progress to scleroderma-like lesions. Hyperbilirubinemia in newborns.
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