Xylometazoline


Concise Prescribing Info
Indications/Uses
Nasal congestion.
Dosage/Direction for Use
Adult : Nasal As 0.1% drops: Apply 2-3 drops bid-tid into each nostril. As 0.1% metered-dose spray: 1 spray in each nostril 1-3 times daily. As 0.1% spray: 1 spray bid-tid into each nostril. Max duration: 5 days.
Dosage Details
Nasal
Nasal congestion
Adult: As 0.1% drops: Apply 2-3 drops bid-tid into each nostril. As 0.1% metered-dose spray: 1 spray in each nostril 1-3 times daily. As 0.1% spray: 1 spray bid-tid into each nostril. Max duration: 5 days.
Child: <6 years As 0.05% drops: Contraindicated. 6-12 years As 0.05% drops/spray: 1-2 drops/spray into each nostril 1 or 2 times daily. Max duration: 3 days.
Contraindications
Undergo trans-sphenoidal hypophysectomy or surgery exposing dura mater, narrow angle glaucoma, atrophic rhinitis. Children <6 years.
Special Precautions
Patient with CV disease, hypertension, diabetes mellitus, hyperthyroidism, prostatic hyperplasia or urinary obstruction. Elderly, children >6 years. Pregnancy and lactation.
Adverse Reactions
Significant: Local irritation, burning sensation in the nose and throat, rebound congestion. Hallucinations, restlessness, sleep disturbances in children. Rarely, transient visual impairment, tachycardia.
Cardiac disorders: Palpitations.
Gastrointestinal disorders: Nausea.
General disorders and administration site conditions: Mucosal dryness.
Nervous system disorders: Headache.
Respiratory, thoracic and mediastinal disorders: Dry nose, nasal discomfort.
Patient Counseling Information
Avoid excessive or prolonged use.
Drug Interactions
Enhanced adverse effects with other sympathomimetics. Risk of hypertensive crisis with MAOIs or TCAs.
Action
Description: Xylometazoline is a direct-acting sympathomimetic agent that produces vasoconstriction in the nasal mucosa thereby decreasing nasal blood flow and congestion.
Onset: Within 5-10 minutes.
Duration: 10 hours.
Chemical Structure

Chemical Structure Image
Xylometazoline

Source: National Center for Biotechnology Information. PubChem Database. Xylometazoline, CID=5709, https://pubchem.ncbi.nlm.nih.gov/compound/Xylometazoline (accessed on Jan. 24, 2020)

Storage
Store between 20-25°C. Protect from heat.
ATC Classification
R01AA07 - xylometazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
References
Anon. Xylometazoline. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 28/02/2018.

Aqua Maris Fast Acting Decongestant (JGL North America LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/02/2018.

Aqua Maris Kids Fast Acting Decongestant (JGL North America LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/02/2018.

Buckingham R (ed). Xylometazoline Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2018.

Joint Formulary Committee. Xylometazoline Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2018.

Disclaimer: This information is independently developed by MIMS based on Xylometazoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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