Most of the adverse reactions observed in clinical trials were of a mild and transient nature.
Gastrointestinal: Diarrhea, loose stools, abdominal pain, dyspepsia, nausea and vomiting. Several cases of documented pseudomembranous colitis were identified during the studies. The onset of pseudomembranous colitis symptoms may occur during or after therapy.
Hypersensitivity: Skin rashes, urticaria, drug fever and pruritus. Erythema multiforme, Stevens-Johnson syndrome and serum sickness-like reactions have been reported.
Hepatic: Transient elevations in serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT) and alkaline phosphatase.
Renal: Transient elevations in blood urea nitrogen (BUN) or creatinine.
Central Nervous System: Headaches or dizziness.
Hemic and Lymphatic Systems: Transient thrombocytopenia, leukopenia and eosinophilia. Prolongation in prothrombin time was seen rarely.
Others: Genital pruritus, vaginitis and candidiasis.