Carbamazepine: Elevated carbamazepine levels have been reported in post-marketing experience when Zifex Plus is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.
Drug/Laboratory Test Interactions: A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide.
The administration of Cefixime may result in a false-positive reaction for glucose in the urine using Clinitest, Benedicts' solution or Fehling's solution. It is recommended that glucose tests based on enzymatic glucose oxidase reactions (eg, Clinistix or Tes-Tape) be used.
A false-positive direct Coombs' test has been reported during treatment with other cephalosporin antibiotics; therefore, it should be recognized that a positive Coombs' test may be due to cefixime.