Before therapy with Zifex Plus is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins or other drugs.
Cefixime should be prescribed with caution in individuals with a history of gastrointestinal disease particularly colitis.
Increased prothrombin time may occur; therefore, care should be taken in patients receiving anticoagulant therapy.