Hypersensitivity to sitagliptin phosphate monohydrate, metformin hydrochloride or to any of the excipients of Ziglip M.
Diabetic ketoacidosis, diabetic precoma, moderate and severe renal impairment (CrCl <60 mL/min).
Acute conditions with the potential to alter renal function eg, dehydration, severe infection, shock, intravascular administration of iodinated contrast agents.
Acute or chronic disease which may cause tissue hypoxia eg, cardiac or respiratory failure. Hepatic impairment, acute alcohol intoxication, alcoholism, breastfeeding.