Ziglip-M Drug Interactions

metformin + sitagliptin


Zifam Pinnacle


Pinnacle House
Full Prescribing Info
Drug Interactions
Co-administration of multiple twice daily doses of metformin 1000 mg with sitagliptin 50 mg did not meaningfully alter the pharmacokinetics of sitagliptin and metformin in patients with type 2 diabetes.
Ciclosporin: Co-administration of a single 100-mg oral dose of sitagliptin and a single 600-mg oral dose of ciclosporin increased the AUC and Cmax of sitagliptin by approximately 29% and 68%, respectively. These changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful. The renal clearance of sitagliptin was not meaningfully altered. Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
Digoxin: Sitagliptin had a small effect on plasma digoxin concentrations. However, patients at risk of digoxin toxicity should be monitored for this when sitagliptin and digoxin are administered concomitantly.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in