Zisuva 625/Zisuva 1G

Zisuva 625/Zisuva 1G

amoxicillin + clavulanic acid

Manufacturer:

Zifam Pinnacle

Distributor:

Pinnacle House
Concise Prescribing Info
Contents
Co-amoxiclav (amoxicillin & clavulanic acid). Per Zisuva 625 FC tab Amoxicillin 500 mg, clavulanic acid 125 mg. Per Zisuva 1G FC tab Amoxicillin 875 mg, clavulanic acid 125 mg
Indications/Uses
Otitis media, sinusitis, & infections caused by susceptible organisms involving the lower resp tract, skin & skin structure, & urinary tract w/ additional coverage of β-lactamase producing B. catarrhalis, H. influenzae, N. gonorrhoeae, & S. aureus (not MRSA) in patients w/ amoxicillin resistance & those who cannot tolerate alternative treatments.
Dosage/Direction for Use
Adult & childn >12 yr Mild-moderate infections 625 mg tab bd. Severe infections 625 mg tab tds or 1 g tab bd. Renal impairment in adult: CrCl >30 mL/min (mild) 625 mg tab bd or 1 g tab bd; 1 g tab should only be used in patients w/ GFR >30 mL/min, CrCl 10-30 mL/min (moderate) 625 mg tab bd, CrCl <10 mL/min (severe) Not more than 625 mg tab every 24 hr.
Administration
May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort. Swallow whole tab, do not break.
Special Precautions
History of β-lactam hypersensitivity, sensitivity to multiple allergens, or previous lgE-mediated reactions eg, anaphylaxis, angioedema, urticaria. Asthmatic patients. Risk of cross-allergy w/ cephalosporins; diarrhea, hepatic effects. Prolonged use may result to fungal/bacterial superinfections including C. difficile-associated diarrhea & pseudomembranous colitis. Rash development during therapy in patients w/ infectious mononucleosis. Hepatic & renal impairment. Avoid use during pregnancy. Lactation. Childn ≤12 yr.
Adverse Reactions
Diarrhea/loose stools, nausea, skin rashes & urticaria, vomiting, vaginitis.
Drug Interactions
Potential for allergic or hypersensitivity reactions to amoxicillin may be enhanced by allopurinol. Therapeutic effect of penicillins may be diminished (by fusidic acid & tetracycline derivatives) & excretion decreased (by uricosuric agents). Penicillins may decrease excretion of methotrexate & serum conc of mycophenolate active metabolite. May diminish the therapeutic effect of typhoid vaccine (only the live attenuated Ty21a strain).
MIMS Class
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Zisuva 1G FC tab
Packing/Price
1 × 10's
Form
Zisuva 625 FC tab
Packing/Price
2 × 7's
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